Combos · Mid

Cassiopeia combos

the Serpent's Embrace

3 Cassiopeia combos explained key by key: in which order to cast the abilities, when to use them and what each step does. The main combo is Q › E › E › W. Further down: every ability's cooldown, cost and range, and the skill max order measured over ranked games.

Cassiopeia combos

Written guide · based on the official ability texts

The poison combo

When: An enemy is within range.

Noxious Blast poisons after a short delay and speeds you up if it hits a champion, then Twin Fang deals more damage to poisoned targets.

The facing ultimate

When: Several enemies are facing you.

Petrifying Gaze stuns those facing you and slows those turning their back: position yourself so they look toward you.

Anti-mobility

When: An enemy uses movement abilities.

Miasma grounds those crossing the clouds: they cannot use movement abilities.

Common mistakes

Casting the ultimate with your back to the enemies: they are only slowed.
Using Twin Fang without poison.
Placing Miasma without using its grounding effect.

Cooldowns, costs and ranges

A combo only comes back once its abilities are off cooldown: these values (rank 1 to max rank, in seconds) tell how long to wait between two combos. Source: Data Dragon 16.19.1.

Ability	Cooldown (s)	Cost	Range
Q · Noxious Blast	3.5	50/55/60/65/70 Mana	850
W · Miasma	24/22/20/18/16	70/75/80/85/90 Mana	700
E · Twin Fang	0.75	45 Mana	700
R · Petrifying Gaze	120/100/80	100 Mana	825

Official ability descriptions

PassiveSerpentine Grace

All Move Speed bonuses are more effective on Cassiopeia.

QNoxious Blast

Cassiopeia blasts an area with Poison after a brief delay, granting her increased Move Speed if she hits an enemy champion.

WMiasma

Cassiopeia releases several clouds of poison, slowing, grounding, and lightly damaging enemies that pass through them. Grounded enemies cannot use Movement abilities.

ETwin Fang

Cassiopeia lets loose an attack that deals increased damage to Poisoned targets and heals her for a percentage of the damage dealt. If the target dies from this attack, Cassiopeia regains Mana.

RPetrifying Gaze

Cassiopeia releases a swirl of magical energy from her eyes, stunning any enemies in front of her that are facing her and slowing any others with their back turned.

Skill order

Max order: E > Q > W56.1% · 41 games

	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15
Q		●						●		●		●	●
W				●										●	●
E	●		●		●		●		●
R						●					●

The order shows which abilities reach rank 5 first; the grid shows the most-played level-up sequence with that order (measured over 46 games).

Riot's official tips for playing Cassiopeia

Use Twin Fang on poisoned stationary targets like monsters and units stunned by her Petrifying Gaze for maximum damage.
Lead your enemy when targeting with Noxious Blast to ensure the hit.

How to play around Cassiopeia's combos

Be wary of Cassiopeia's damage potential with Twin Fang when she has you poisoned.
Turn away from Cassiopeia when she is casting Petrifying Gaze to get slowed instead of stunned.

Frequently asked questions

What is Cassiopeia's main combo?

The poison combo: Q › E › E › W. An enemy is within range. Noxious Blast poisons after a short delay and speeds you up if it hits a champion, then Twin Fang deals more damage to poisoned targets.

Which ability should I max first on Cassiopeia?

The most-played max order is E > Q > W (41 games, 56.1% win rate).

What is the cooldown of Cassiopeia's ultimate?

Petrifying Gaze has a 120/100/80 second cooldown depending on its rank.

Build, runes and counters: full Cassiopeia guide · every champion's combos · tier list